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Protein Phase Transition: From Biology Towards New Protein Materials
We identify the role of ATP and RNA in triggering the nucleation and growth of the protein-rich droplets, as well as in maintaining the protein dense phase in the liquid state. These results reveal molecular mechanisms that cells have plausibly developed to accurately control the reversible assembly and the biophysical properties of P-bodies.
Protein Phase Separation: A New Phase in Cell Biology - PMC
In this review, we examine the current state of the growing interest in membraneless organelles, providing insights into their biogenesis, organization, dynamics, regulation, and function. We also discuss how recent findings can give us molecular insights in age-related diseases.
Amyloid formation as a protein phase transition - Nature
Amyloid formation is a transition between the dilute solution phase of a protein and a solid β-sheet-rich aggregated phase that occurs through nucleation-and-growth processes. Uncontrolled...
Phase Separation, Transition, and Autophagic Degradation of Proteins in ...
Phase separation and transition control the assembly and material states (liquid, gel like, or solid) of protein condensates to ensure that distinct cellular functions occur in a spatiotemporally controlled manner.
Functional Biomaterials Derived from Protein Liquid–Liquid Phase ...
Protein phase transitions play a vital role in both cellular functions and pathogenesis. Dispersed proteins can undergo liquid–liquid phase separation to form condensates, a process that is reversible and highly regulated within cells.
Various levels of phase transitions in the protein universe and around
Proteins, edited by evolution, undergo and participate in various intra- and inter-molecular phase transitions. Intramolecular phase transitions define the spontaneous folding of globular proteins and the binding-induced folding of intrinsically disordered proteins.
Phase transitions as intermediate steps in the formation of molecularly ...
Our results show a link between protein architecture and phase separation behavior suggesting a general approach for understanding protein assembly from dilute solutions into functional structures.
Control Intracellular Protein Condensates with Light
Optogenetic techniques present us with a potential means to control protein phase behavior with spatiotemporal precision. This review delves into the design of optogenetic tools, particularly those aimed at manipulating protein phase transitions in complex biological systems.
Protein Phase Separation as a Stress Survival Strategy - PMC
We propose that protein phase separation is an evolutionary conserved feature of proteins that cells harness to regulate adaptive stress responses and ensure survival in extreme environmental conditions.
LLMs predict protein phases - Nature Methods
Proteins normally exist in soluble form but can undergo a phase transition to a dense liquid phase via liquid–liquid phase separation (LLPS) or to solid aggregates such as amyloids.
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